One trial involves using the blood of recovered Ebola patients to treat sick people in the Guinean capital Conakry.
Two antiviral drugs will be trialled in Guinea and an unconfirmed location.
“This is an unprecedented international partnership which represents hope for patients to finally get a real treatment,” said MSF spokeswoman Dr Annick Antierens.
The first trials are due to start next month. Initial results could be available in February 2015.
The World Health Organization announced in September that experimental treatments and vaccines for Ebola should be fast-tracked.
Two experimental vaccines, produced by GlaxoSmithKline (GSK) and the Public Health Agency of Canada, have already been fast-tracked into safety trials.
The GSK vaccine is being tested in Mali, the UK and the US. Research on the Canadian vaccine is also under way in the US.
The three latest trials are:
At the Donka Ebola centre in Conakry, Guinea, led by the Antwerp Institute of Tropical Medicine (ITM), involving convalescent blood and plasma therapy – using blood from recovered patients containing antibodies that successfully fought off the virus to boost the patient’s immune system
At a site yet to be officially announced, funded by the Wellcome Trust and led by the University of Oxford, using the antiviral drug brincidofovir. It works by interfering with the virus’ ability to multiply. Up to 140 consenting patients will take the tablets twice a week over a two week period, and survival rates will be compared to those before the trial
In Gueckedou, Guinea, led by the French National Institute of Health and Medical Research (Inserm), using the antiviral drug favipiravir.
There have been some anecdotal studies in previous outbreaks suggesting blood transfusions could benefit Ebola patients, but there is no scientifically proven evidence. This will be the first time there has been a human trial on any significant scale.
Speaking to the BBC from Conakry, lead researcher from ITM Johan van Griensven said:
“There are three important components [of this study] – the first is identifying Ebola survivors willing to donate blood. The second is the actual blood collection, and the third is the administration of the blood [to Ebola patients].”
However, organising safe blood donations in countries with decimated health systems is an enormous task.
Donating and taking blood is also extremely culturally sensitive in affected countries.
“There will be an anthropological assessment which will hopefully give us the information we need to understand a bit better how such a study would be perceived by the community” said Mr van Griensven.
“It will also give us a deeper understanding of the perspectives of people who have survived Ebola because suddenly they could have a specific role within the whole scale of treatment for other patients.
“This will be a key component to help us start implementing this study in a respectful and appropriate manner.”
Dr Antierens from MSF also said community engagement was a key priority.
“Each patient who consents to be part of a trial will have the potential risks of being subjected to a new therapy clearly explained,” she said.
MSF said these trials were “an exceptional measure in exceptional circumstances” as they try to bring the outbreak under control.
Credit: The BBC